Identification of novel peptide hormones in the human proteome by hidden Markov model screening

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Figure 7.
Figure 7.

Spexin is a biologically active peptide hormone. (A) Representative muscle contractile response to 10 μM acetylcholine (ACh) and 1 μM spexin peptide (NWTPQAMLYLKGAQ-amide) in a rat stomach explant assay. Repeated administration of spexin peptide produced similar contactile responses. (B) Cumulative dose-response curve for contractile activity of spexin peptide on rat stomach explants (EC50 = 0.75 μM, N = 6). Error bars indicate standard error.

This Article

  1. Published in Advance February 6, 2007, doi: 10.1101/gr.5755407 Genome Res. 17: 320-327

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