Evolutionary history of the centromeric WFDC sublocus. The major duplication, deletion, rearrangement, and pseudogenization events involved in the evolution of the centromeric WFDC sublocus since the split of rodents and primates are schematically cataloged. In each case, the two paralogous duplicons (configured in a head-to-head fashion) within the sublocus are represented by two horizontal rectangles. Solid and open circles indicate functional genes and nonfunctional pseudogenes, respectively; black, red, and blue circles represent WFDC, trappin, and SEMG/Svs genes, respectively. Genes are labeled A through O, with the specific names provided in the key at the bottom. The blue squares depict the two SEMG1 genes in squirrel monkey, which are the result of a gene-conversion event. A blue triangle depicts the single SEMG gene in owl monkey (a SEMG1-SEMG2 chimera). The evolutionary history of each gene can be traced along the indicated lineages by the colored lines. Divergence times are provided on the right (MYA, million years ago), as indicated by Goodman et al. (1998); note that this evolutionary timeline is not drawn to scale.
