E2F family members show little cell type specificity in binding. (A) Shown are the five cell types used in this study, with an indication of how they are organized into different comparison sets. (B) A comparison of the top 100 E2F1, E2F4, or E2F6 target promoters in both normal cells (GM06990 vs. MCF10A), in the normal vs. tumor breast cells (MCF10A vs. MCF7), and in all pairwise comparisons of the three tumor cell lines is shown; a combined list of the names for the top 100 E2F target promoters in the five cell types is provided as Supplemental Table S4. (C) A comparison of the top 2000 E2F1, E2F4, or E2F6 target promoters in both normal cells (GM06990 vs. MCF10A), in the normal vs. tumor breast cells (MCF10A vs. MCF7), and in all three tumor cell lines is shown.
