A comprehensive ChIP–chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members

The E2F family. Shown is a schematic comparing the domain structure of E2Fs 1–8; not shown are the lower abundance isoforms of E2F6 (Kherrouche et al. 2004). We have chosen E2F1 as a representative of the class of E2F family members that contains the N-terminal cyclin binding domain and the C-terminal RB1 family binding domain, E2F4 as a representative of the class of E2F family members that lacks the cyclin binding domain but contains the RB1 family member binding domain, and E2F6 as a representative of the class of E2F family members that are thought to function as repressors in an RB1-independent manner.