Prediction of individual genetic risk to disease from genome-wide association studies

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Figure 3.
Figure 3.

Relationship between disease prevalence (K) and heritability (h2) on number of risk loci contributing to a disease, assuming a fixed frequency of risk alleles (p) and fixed RR of 1.1 (Equation 3). Based on results from Figure 1, p = 0.1 approximates to the neutral model and p = 0.5 approximates to the CDCV model.

This Article

  1. Published in Advance September 4, 2007, doi: 10.1101/gr.6665407 Genome Res. 17: 1520-1528

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