Computational identification and functional validation of regulatory motifs in cartilage-expressed genes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 3.
Figure 3.

Mutational analyses of computationally predicted paired SOX-binding motifs in the Mia promoter. RCS cells were transiently transfected (in triplicate experiments) with either the full-length Mia (−2251 bp mouse) promoter (required for chondrogenic expression), truncated promoter (−401), or with mutations in the computationally predicted SOX-binding motifs (CA to GG) (−410m and −395m).

This Article

  1. Published in Advance September 4, 2007, doi: 10.1101/gr.6224007 Genome Res. 17: 1438-1447

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research