Top 10 regions of biased clustered substitutions in humans
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A surprising number of genes appear in the list of regions showing the most substitution bias (8 out of 10 are transcribed). VLDLR, HAR1, CHL1, and HTR5B are all involved in brain development or function. DPP10 is associated with asthma. AF123758 is a putative transmembrane protein that may be implicated in a neurodegenerative disorder. Regions 1 and 4 are predicted genes transcribed in mammals. W-to-S = weak-to-strong (Matthes et al. 1993; Webb et al. 1994; Burge 1998; Wei et al. 1998; Chen et al. 2003; Benson et al. 2004; Pollard et al. 2006b).
