Figure 5.
Quantitative expression data for IL13 from expression profiles performed on 15 CEPH families using a 25K human gene oligonucleotide microarray (Monks et al. 2004) are correlated with genotype at rs11739417 and demonstrate a reduction in mean IL13 production for AG heterozygotes compared to AA homozygotes (t-test, P = 0.016). These independent expression data support the conclusions from ATR mapping, namely, that allele G at rs11739417 (and haplotype A4 to which allele G is unique) is associated with a reduction in IL13 expression.
