Figure 1.
An example of intron loss in the mouse ortholog of the human DYNC1H1 gene, visualized in the UCSC Genome Browser display of multispecies alignments. Uppercase, boxed sequences correspond to exons. Note that the alignment is inexact at the splice sites, resulting in an artifactual 3-bp intron length in mouse, which necessitates an approximate search strategy (described in Methods), and realignment of sequences using an appropriate parameter choice in order to confirm all candidate intron deletions. Realigned sequences of the introns and neighboring exons for all 120 cases of intron loss are provided in Supplemental data.
