Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length

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Figure 4.
Figure 4.

Hybridization of 12 Tb427-chrIb-derived probes to dot-blots of Tb927 and Tb427 total DNA (A) and Southern blots of Tb427 chromosomes (B). In dot-blot experiments most probes hybridize only to Tb427, although in some cases the lower stringency of this experiment (compared with the initial screening) allows cross-hybridization to similar VSG families in Tb927. (Black dots) Hybridization to chrIb (fully resolved in this gel), (black stars) hybridization to the chrIa homolog (here compressed with other chromosomes), (ChrI) chrI-specific gene probe, (CZ) compression zone containing chrs VIIIb, IXb, Xab, and XIab (∼40% of megabase genome). See Supplemental Table S2 for additional information on each of the probes.

This Article

  1. Published in Advance August 9, 2006, doi: 10.1101/gr.5147406 Genome Res. 16: 1109-1118

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