Comparative isoschizomer profiling of cytosine methylation: The HELP assay

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Table 2.

Cross-correlation of HELP results with genomic annotations

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Table 2.

Substantial proportions of CpG islands and promoters fall into the methylated category, as defined by our threshold of a 0.15 centered HpaII/MspI log ratio value. In addition, a minority of repetitive sequences falls into the hypomethylated category, indicating that cytosine methylation may have a more complex intragenomic distribution than previously believed.

This Article

  1. Genome Res. 16: 1046-1055

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