
Schematics of F-box and MATH-BTB protein domains. Domain schematics of the main types of proteins analyzed in this paper, including three types of F-box domain proteins and MATH-BTB domain proteins. Domains that bind Cullins are shades of blue, and domains that bind substrate are shades of yellow to brown. F-box family A2 has an additional domain (M for mariner, shown in green) of unknown function that is related to the DNA-binding domain of mariner transposases. The region of highest sequence diversity in each F-box family is labeled hypervariable.











