Figure 1.
Cross-linking events that may yield enriched DNA fragments by chromatin immunoprecipitation of an RNA binding protein (RBP). HeLa cells were cross-linked with 10 mM DMA and 1% formaldehyde (cross-linking events depicted as red x’s). This approach should increase the frequency of protein–protein and protein–DNA cross-linking, enabling the detection of both direct and indirect protein–DNA interactions.
