Close sequence comparisons are sufficient to identify human cis-regulatory elements

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Figure 5.
Figure 5.

SCL locus: Benchmarking eutherian sequence comparison against empirical data. The displayed 60-kb genomic region contains the SCL gene and its flanking intergenic regions. Human–mouse–rat–dog CNSs (red) and exonic (blue) conserved regions identified by Gumby (P-value ≤ 0.5) are shown as vertical bars. The nine CNSs marked with asterisks identify 8/10 benchmark sequence elements with empirical evidence of cis-regulatory function (green rectangles). Additionally, there are 11 new predictions at this P-value threshold.

This Article

  1. Published in Advance June 12, 2006, doi: 10.1101/gr.4717506 Genome Res. 16: 855-863

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