Information regarding the six drug target genes in which a new AS event was found
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(GSTP1) Glutathione S transferase π; (GUSB) β-glucuronidase; (P4HA2) α2 subunit of prolyl 4-hydroxylase; (FOLR2) folate receptor 2 (fetal); (HSD3B1) 3-β hydroxysteroid dehydrogenase; (PRL) prolactin. Columns 3 and 4 indicate, respectively, the number of ESTs and ASSETs covering the corresponding gene. Column 7 gives the identity of one ASSET documenting the corresponding event. Note that the six AS events described here have all been identified exclusively thanks to the AS library (column 6). Note also that the new exon truncation event found within the FOLR2 gene displays the rare GC–AG splice-site motif instead of the standard GT–AG motif. Using the ID sequence (column 7) as an entrance key, the above six AS events can be seen through a graphical interface (http://www.genoscope.cns.fr/cgi-bin/ggb/splicing_human/gbrowse/Human), where it is possible to compare the alignment on the genomic DNA of the ID sequence and the cDNAs retrieved from the Ensembl transcript and H-Invitational databases. The genomic positions encompassing the events are as follow: GSTP1, K11_67129103_67129220; GUSB, K7_64844511_64846918; P4HA2, K5_131630554_131639699; FOLR2, K11_71654278_71655983; HSD3B1, K1_119396626_119400507; and PRL, K6_22405288_22410968.
