Figure 3.
Use of conserved synteny in pseudogene finding. (A) A pseudogene (pink) on human chromosome 7 was inserted between two genes (blue and orange) (B). This part of human chromosome 7 is orthologous to a region on mouse chromosome 5. If the processed pseudogene in human was generated after the mouse–human split, it will not be present in the orthologous region in the mouse. Instead, the best match in the mouse genome is the location that is orthologous to the parent of the pseudogene.
