Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression

Many TFs preferentially bind to specific regions relative to the TSS of their target genes. A heat map of the enrichment (represented as a Z-score) of a TF for different regions relative to TSSs is shown. Regions in red are highly enriched for binding sites for the given TF, while those in blue are depleted. The regions shown on the x-axis are as follows: >100kb upstream, pCRMs located more than 100 kb upstream from a TSS; 10–100kb upstream, pCRMs located >10 kb, but <100 kb upstream from a TSS; 1–10kb upstream, pCRMs located >1 kb but <10 kb upstream from a TSS; 0–1kb upstream, pCRMs located within 1 kb upstream of a TSS; 1kb 1^st intron, intronic pCRMs located within 1 kb downstream of the TSS of a gene; 10kb 1^st intron, intronic pCRMs located within 10 kb downstream of a TSS; intron, intronic pCRM located >10 kb from the TSS; 0–1kb down, pCRM located within 1 kb from the 3′ end of a gene; 1–10kb down, pCRM located >1 kb but <10 kb downstream from the 3′ end of a gene. See Methods for details on the computation of Z-scores.