Results for the three regulatory network expansion scenarios (A,B,C) using a combination of the iMH805/775 network and a provisional regulatory network derived from ChIP-chip and TF-binding motif data. Each pie chart indicates the fractions of potential target genes that can be reached from the TF through regulatory cascades containing one to five steps as well as the targets that cannot be reached in five or less steps from the TF. For each strain, the numbers of potential novel targets are indicated in parenthesis. (A) Expansion using ChIP-chip and motif data for the 55 TFs in iMH805/775 assuming that each TF can only act as a repressor or activator depending on its known type of activity. (B) Expansion using the same ChIP-chip and motif data, but allowing each TF to act either as repressor or activator. (C) Expansion using ChIP-chip and motif data for all 203 TFs studied in Harbison et al. (2004) allowing each TF to act either as repressor or activator.
