Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes

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Figure 2.
Figure 2.

Diagrams of the KRAB-ZNF clusters on HSA1, HSA4, and HSA7 containing genes related to the ZNF91 subfamily. Maps show the physical order of the KRAB-zinc finger loci in the clusters, but are not scaled for genomic distance or relative size. Due to the spacing between loci, the HSA7 map shown could be defined as more than one cluster, but several clades of closely related loci (colored to match Fig. 3) have copies distributed across the region. Symbols and labels for genes and β-satellite repeats are the same as in Figure 1. The red arrows under the HSA1 cluster denote the two ZNF91 subfamily members in that cluster (the blue outline boxes denote KRAB-C subfamily genes). The HSA7 region shown also has a divergent gene at the p-telomeric end (ZNF713) included in the diagram although relationships between this gene and other KRAB-ZNF loci are unclear. Not shown are four clusters containing a total of 15 pseudogene loci on HSAY and three divergent loci (ZNF267, ZNF720, LLNL1128), which may be distant relatives of the ZNF91 subfamily, clustered together with unrelated genes on HSA16.

This Article

  1. Genome Res. 16: 584-594

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