Computational modeling of the Plasmodium falciparum interactome reveals protein function on a genome-wide scale

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Figure 4.
Figure 4.

A subset of high confidence links as visualized by Large Graph Layout package (LGL, Adai et al. 2004). The subset of links at a score threshold of 14 or greater contains 10× the number of true positives than false positives when measured against our gold standards. Several functionally relevant subnetworks, such as that of proteins involved in transport, DNA polymerases, and histone proteins, are also illustrated. These subnetworks also reveal the various types of functionally relevant associations available; members that constitute parts of pathways, possess similar function, or even are subunits of protein complexes are visible. Edges in the graph are unweighted.

This Article

  1. Genome Res. 16: 542-549

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