Genetic mapping of two recessive mutations with the SNP panel. Only data from informative SNPs for each mapping cross are shown. SNP names are displayed on the right. The mutated strain (M) for each mutant is red; background strain (B), blue; heterozygotes, yellow; and No Calls, white. A plot of LOD scores is shown. The vertical line indicates a LOD score of zero, with the boundaries, –52 (left) and 7.2 (right). (A) Retention of mutated alleles (C57BL/6J; LOD 5.38) in baldy affecteds (denoted as A) on distal Chr. 14 demonstrates linkage of SNP C14.065.150 (62.3 Mb) to the baldy locus. (B) Retention of mutated alleles (A/J) demonstrates linkage of hydrops fetalis to Chr. 7. Because of limited informativeness on Chr. 7 between A/J and FVB/NJ, the strain contribution of A/J or FVB/NJ is potentially ambiguous. However, allele origin can be inferred across haplotypes by the retention of A/J alleles for two A/J and FVB/NJ polymorphic SNPs (07.023.307 and 07.039.006).
