Table 4.
Top ranking transcription factors predicted in cholesterol biosynthesis genes
|
Accession |
Factor |
Consensus |
〈R-score 〉 |
P-value |
|---|---|---|---|---|
| M00287 | NF-Y | RRCCAATSRG | 3.381 | ∼0 |
| M00801 | CREB | CGTCAN | 2.18 | 0.019 |
| M00413 | AREB6 | WCACCTGW | 2.104 | 0.0089 |
| M00059 | YY1 | CCATNTW | 1.808 | 0.0589 |
| M00716 | ZF5 | GSGCGCGR | 1.772 | 0.2331 |
| MA0089 | TCF11-MafG | NATGAC | 1.754 | 0.2127 |
| M00322 | c-Myc | GCCAYGYGS | 1.749 | 0.0665 |
| M00188 | AP-1 | RGTGACTMA | 1.72 | 0.1044 |
| M00217
|
USF
|
CACGTG
|
1.698
|
0.1733
|
-
Experimentally validated transcription regulators of cholesterol biosynthesis genes, such as NF-Y and CREB, were predicted as top ranking transcription factors. Other high scoring TFs predicted with higher P-values are likely to regulate a subset of these cholesterol biosynthesis genes.
