Logistic regression protects against population structure in genetic association studies

Table 5.

The percentage of the 50 data sets under each demographic scenario for which, when the causal SNP is excluded, at least one of the nine other SNPs in gene 1 is significantly associated with disease



Power (%): Causal SNP excluded
FST/struct
CHISQ
GC
SLR
BLR
STR2
AM2
(1) No structure 86 82 84 84 62 84
(2) Low/eq 88 84 94 88 62 86
(3) High/eq 76 60 68 72 58 68
(4) Low/un 74 68 72 72 72 72
(5) High/un 70 60 68 66 66 66
Average (SE)
79 (2.8)
71 (3.1)
77 (2.9)
76 (2.9)
64 (3.4)
75 (3.0)
  • The final row gives the mean over the first five rows, and its standard error (SE).

This Article

  1. Genome Res. 16: 290-296

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