Table 3.

Neutrality tests for each continental region and for all the samples together (world)

	Africa	Africa A	Africa B	Europe	West Asia	East Asia	Pacific	America^a	World	World (R = 2.79)
S	14	12	11	6	6	5	3	1	23	23
2N	68	28	40	104	64	64	32	16	348	348
Tajima's D	– 1.34	– 1.43	– 1.32	– 1.20	– 0.87	– 1.64	– 0.60	–	– 2.02	– 2.02
P-value	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	–	Significant	Significant
	P > 0.10	P > 0.10	P > 0.10	P > 0.10	P > 0.10	0.10 > P > 0.05	P > 0.10		P < 0.05	P < 0.001
Fu and Li's D^*	– 1.06	– 1.29	– 0.73	– 2.73	– 1.53	– 0.93	– 0.28	–	– 3.77	– 3.77
P-value	N.S.	N.S.	N.S.	Significant	N.S.	N.S.	N.S.	–	Significant	Significant
	P > 0.10	P > 0.10	P > 0.10	P < 0.05	P > 0.10	P > 0.10	P > 0.10		P < 0.002	P < 0.005
Fu and Li's F^*	– 1.38	– 1.56	– 1.08	– 2.62	– 1.55	– 1.35	– 0.43	–	– 3.69	– 3.69
P-value	N.S.	N.S.	N.S.	Significant	N.S.	N.S.	N.S.	–	Significant	Significant
	P > 0.10	P > 0.10	P > 0.10	P < 0.05	P > 0.10	P > 0.10	P > 0.10		P < 0.001	P < 0.001
Fu's F	– 17.61	– 6.71	– 7.85	– 3.50	– 1.41	– 6.60	– 0.93	–	– 47.28	– 47.28
P-value	Significant	Significant	Significant	N.S.	N.S.	Significant	N.S.	–	Significant	Significant
	P < 0.0005	P < 0.006	P = 0.003	0.10 > P > 0.05	P > 0.10	P < 0.002	P > 0.10		P < 0.001	P < 0.001
Fay and Wu's H	– 0.80	– 0.73	– 0.92	0.38	0.29	0.49	0.46	–	– 1.37	– 1.37
P-value	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	–	N.S.	N.S.
	P > 0.10	P > 0.10	P > 0.10	P > 0.10	P > 0.10	P > 0.10	P > 0.10		P > 0.10	P > 0.10

Significance of Tajima's D, Fu and Li tests. Fu's F and Fay and Wu's H are calculated by coalescent simulations using Dnasp 4.00. For the world sample, values of P for all neutrality tests are also calculated by taking into account recombination (R = 2.79).

N.S. is nonsignificant (>0.05).
↵a Note that only a single SNP is found and these tests have not been computed in this group

The prion protein gene in humans revisited: Lessons from a worldwide resequencing study