The prion protein gene in humans revisited: Lessons from a worldwide resequencing study

Table 2.

Haplotypes found in exon 2 of the PRNP gene
R
D
I
1
1
1
1
1
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2 E N 1 2 4 7 7 1 3 6 6 6 6 6 6 6 6 7 7 7 7 7
L S 7 9 2 1 7 9 2 2 2 3 6 8 8 8 9 0 0 4 6 8
C C 1 8 7 1 0 8 9 0 1 7 9 2 0
5
 1
 2
 1
 3
 3
 3
 8
 1
 9
 5
 3
 2
Europe
 W-Asia
 E-Asia
 Africa A
 Africa B
 Pacific
 America
R D I T
S1 2 C C A A G A C G T A G A T T C A A C T T T G 216 72 36 56 9 16 23 4
S4 . . . . . . . . . . . . . . . . . . . . . . C 1 1
S5 . . . . . . . . . . . . . . . G . . . . . . . 2 2
S6 . . . . . . . . . . . A . . . . . . . . . . . 1 1
S7 . . . . . . . . A . . . . . . . . . . . . . . 3 3
S9 . – . . . . . . . . . . . . . . . . . . . . . 5 1 4
S10 . . . . . . . . . . . . . . . . . G . . . . . 1 1
S11 . . + . . . . . . . . . . . . . . . . . . . . 1 1
S12 . . . . . . . . . . . . . . . . . . . . . A . 1 1
S13 . . . . . . . . . . . . – . . . . . . . . . . 1 1
S14 . . . . . . . . . G . . . . . . . . . . . . . 1 1
S15 . . . . . . . . A . . . – . . . . . . . . . . 1 1
S17 – . . . . . . . . . . . . . . . . . . . . . . 1 1
S19 . . . . . . . . . . . . . . . . . . . G . . . 1 1
S20 . . . . . A . . . . . . . . . . . . . . . . . 4 2 2
S26 . – . . . . . . . . . . . . . . . . T . . . . 1 1
S27 . . . . . . . . . . . . . . C . . . . . . . . 1 1
S2 . . . . G . . . . . . . . . . . . . . . . . . 87 27 21 3 8 11 5 12
S3 . . . G G . . . . . . . . . . . G . . . . . . 6 1 4 1
S8 . . . . G . . T . . . . . . . . . . . . . . . 1 1
S16 . . . . G . . . A . . . . . . . . . . . . . . 1 1
S18 . . . . G . G . . . . . . . . . . . . . . . . 1 1
S21 . . . . G . . . . . . . . . . . . G . . . . . 1 1
S22 . . . . G . . . . . . . . . . . G . . . . . . 2 2
S23 . . . . G . . . . . . . . C . . . . . . . . . 1 1
S24 . . . . G . . . . . T . . . . . . G . . . . . 3 3
S25 . . . G G . . . . . . . . . . . . . . . . . . 2 2
S28 . . . . G . G . . . . . . . . . . . . . – . . 1 1
348 104 64 64 28 40 32 16
Chimp
.
.
.
.
.
.
G
.
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.
.
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.

  • The first group of haplotypes contain methionine (A) in position 129, while the second group contains valine (G). The arbitrary names of the haplotypes are indicated on the left and the continental region where the haplotype is found on the right. The total haplotypic frequency is also shown. The alleles in chimpanzee are shown only for the human PRNP variable sites.

This Article

  1. Published in Advance December 20, 2005, doi: 10.1101/gr.4345506 Genome Res. 16: 231-239

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