Table 1.
Genotype and allele frequency distribution of codon 129 and codon 219
|
Group |
2N |
Samples failed |
129Met/Met |
129Val/Val |
129Met/Val |
129Met |
129Val |
|---|---|---|---|---|---|---|---|
| Africa | 254 | 1 | 46 (36.5) | 21.4 (27) | 42.1 (53) | 145 (57.5) | 107 (42.5) |
| Middle East/North Africa | 356 | 2 | 89 (50.6) | 20 (11.4) | 67 (38) | 245 (69.6) | 107 (30.4) |
| Europe | 322 | 1 | 75 (46.9) | 12 (7.5) | 73 (45.6) | 223 (69.7) | 97 (30.3) |
| Central/South Asia | 400 | 1 | 98 (49.3) | 11 (5.5) | 90 (45.2) | 286 (71.9) | 4.8 (28.1) |
| East Asia | 502 | 1 | 227 (90.8) | 1 (0.4) | 22 (8.8) | 476 (95.2) | 24 (4.8) |
| Pacific | 78 | 0 | 24 (61.5) | 4 (10.3) | 11 (28.2) | 59 (75.6) | 19 (24.4) |
| America
|
216
|
2
|
16 (15.1)
|
48 (45.3)
|
42 (39.6)
|
74 (34.9)
|
138 (65.1)
|
| Group |
2N |
Samples failed |
219Glu/Glu |
219Lys/Lys |
219Glu/Lys |
219Glu |
219Lys |
|---|---|---|---|---|---|---|---|
| Africa | 254 | 0 | 127 (100) | 0 (0) | 0 (0) | 254 (100) | 0 (0) |
| Middle East/North Africa | 356 | 2 | 174 (98.9) | 0 (0) | 2 (1.1) | 350 (99.4) | 2 (0.6) |
| Europe | 322 | 7 | 154 (100) | 0 (0) | 0 (0) | 308 (100) | 0 (0) |
| Central/South Asia | 400 | 2 | 193 (97.5) | 2 (1) | 3 (1.5) | 389 (98.2) | 7 (1.8) |
| East Asia | 502 | 1 | 236 (94.4) | 0 (0) | 14 (5.6) | 486 (97.2) | 14 (2.8) |
| Pacific | 78 | 2 | 33 (89.2) | 0 (0) | 4 (10.8) | 70 (94.6) | 4 (5.4) |
| America
|
216
|
2
|
106 (100)
|
0 (0)
|
0 (0)
|
212 (100)
|
0 (0)
|
-
Data were obtained by genotyping the entire HGDP-CEPH panel. The total number of chromosomes analyzed was 2128, and the total failures was eight for codon 129 and 16 for codon 219.
