Table 3.
Number of variants in nine SLC transporters that change substrate specificity
|
Gene |
Substrates tested (#) |
Variants tested (#) |
Number of variants with altered substrate specificity (%) |
|---|---|---|---|
| OCT2 | 6 | 4 | 3 |
| 7 | 5 | 0 | |
| OCTN1 | 2 | 6 | 1 |
| OCTN2 | 2 | 8 | 1 |
| OAT3 | 2 | 10 | 1 |
| CNT1 | 2 | 4 | 1 |
| CNT2 | 2 | 3 | 0 |
| 3 | 1 | 1 | |
| CNT3 | 2 | 7 | 0 |
| 5 | 3 | 0 | |
| ENT1 | 2 | 1 | 0 |
| 7 | 1 | 0 | |
| ENT2 | 4 | 5 | 0 |
|
|
Total
|
58
|
8 (14%)
|
