Defining the mammalian CArGome

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Figure 7.
Figure 7.

Autoregulatory loop for SRF-dependent cytoskeletal target gene activation. The schematic models a positive feedback mechanism for SRF-mediated cytoskeletal gene expression wherein actin dynamics stimulate SRF activity, which, in turn, activates genes encoding the cytoskeletal apparatus. We propose this feedback loop is an ancient mechanism for SRF-dependent regulation of normal cytoskeletal homeostasis, which, in turn, is requisite for SRF activity.

This Article

  1. Published in Advance December 19, 2005, doi: 10.1101/gr.4108706 Genome Res. 16: 197-207

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