Table 2.

Statistical significance of amino acid frequency in ancient reading frames and derived reading frames

	P (being over- or underrepresented)^a
Amino acid	Ancient reading frames	Derived reading frames
A	0.088	<0.001 ↑
C	0.432	<0.001 ↑
D	0.119	<0.001 ↓
E	0.003 ↓	<0.001 ↓
F	0.504	<0.001 ↓
G	0.228	<0.001 ↑
H	0.170	<0.001 ↑
I	0.077	<0.001 ↓
K	0.002 ↓	<0.001 ↓
L	0.002 ↑	0.063
M	0.419	0.081
N	<0.001 ↓	<0.001 ↓
P	0.026	<0.001 ↑
Q	0.457	<0.001 ↑
R	0.081	<0.001 ↑
D	0.468	0.079
T	0.370	0.395
V	0.431	<0.001 ↓
W	0.001 ↑	<0.001 ↑
Y	0.196	<0.001 ↓

A genome-wide study of dual coding regions in human alternatively spliced genes