Biologically relevant targets are bound more efficiently in vivo than in vitro
Click on table to view larger version.
Promoters were segregated into groups according to the conditions in which they were bound by Leu3. The genes downstream from the promoters in each category were then used as input for GO Term Finder (Friden and Schimmel 1988). Significantly enriched GO categories (P-value < 0.001) are shown for each promoter group. (A) Promoters bound by Leu3 both in vivo and in vitro at 1% FDR (Methods). (B) Top 30 promoters in the full-length Leu3 ChIP-chip or in the Leu3-DBD ChIP-chip after excluding the promoters in A. (C) Top 30 promoters in the 40 nM Leu3-DBD DIP-chip or in the 4 nM Leu3-DBD DIP-chip after excluding the promoters in A.
