CBX1 binds to the KRAB-ZNF gene family. (A) Most KRAB-ZNF genes on Chr19 are bound by CBX1. Frequency distribution of CBX1 binding to KRAB-ZNF genes (dark gray line), ZNF genes without KRAB domain (light gray line), and non-ZNF genes (thin black line) on Chr19. Black arrowheads indicate average CBX1 binding to four nonclustered KRAB-ZNF genes, i.e., ZNF114, ZNF333, ZNF175, and ENSG00000142528 from left to right. (B) Box-and-whisker plot of CBX1 binding to gene families on Chr19. All gene families that have >10 members on the Chr19 genomic tiling array are shown. To define gene families we used Ensembl protein family IDs (e.g., ENSF00000000001). For comparison we included the KRAB-ZNFs family (identified on the basis of their InterPro IDs; see Methods). The number of genes per family on Chr19 is given in parentheses. Vertical lines represent the smallest value (outliers excepted), the 25th, 50th (median), and 75th percentiles and the largest value (outliers excepted).
