Albertha J.M. Walhout

Unraveling transcription regulatory networks by protein–DNA and protein–protein interaction mapping

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Figure 5.

Deriving biological hypotheses from regulatory networks. (A) A protein–DNA interaction network of C. elegans digestive tract genes was used to derive a three-layered model of transcription regulation. Reprinted with permission from Elsevier © 2006, Deplancke et al. 2006. (B) Example of a protein–DNA interaction network subgraph. (C) Example of a protein–DNA interaction network motif. See main text for details.