Figure 2.
Haploview plot of HapMap linkage disequilibrium coefficient D′ for pairs of SNPs along 21q11. Twenty-five highly informative SNPs were selected along a 963-kb 21q11 region in the Hap-Map database, spanning the previously reported transition between repressed and active domains for meiotic recombination in women (Laurent et al. 2003) and with the most proximal marker 229 kb from α-satellite. High D′ values extend up to 719 kb (SNP ID rs7282547) from the centromeric α-satellite and indicate a repression of recombination in this region. The x-axis is as in Figure 1.
