Regions of high differentiation—Worth a check
Abstract
B. Boursot and K. Belkhir in this issue of Genome Research point to an ascertainment bias in my use of SNPs to identify regions of high differentiation between a pair of house mouse subspecies. Here, I discuss additional points to consider and argue that the ultimate test for such regions should be an independent confirmation using unrelated samples. I provide evidence that regions of high differentiation as identified from laboratory strains and potentially biased SNP markers can be confirmed and therefore are worth a deeper investigation.
Footnotes
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E-mail harrb{at}uni-koeln.de; fax 49-221-470-5975.
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[Supplemental material is available online at www.genome.org.]
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Article is online at http://www.genome.org/cgi/doi/10.1101/gr.5787706.
- Copyright © 2006, Cold Spring Harbor Laboratory Press
