Table 3.
Compilation of hnRNP proteins identified in the analyzed genomes
|
Family |
Human |
Mouse |
Rat |
Chicken |
Fugu |
Zebrafish |
Tetraodon |
Ciona |
Fly |
Mosquito |
C. elegans |
Arabidopsis |
S. pombe |
T. cruzia |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| hnRNP-A | ROA0 | ROA0 | ROA1 | ROA0 | ROA0 | ROA0a | ROA0 | ROA1a | RO87F | RO87F | ROAa | ROAa | ||
| ROA1 | ROA1 | ROA2 | ROA1 | ROA1 | ROA0b | ROA1 | ROA1b | RO97D | ROAb | ROAb | ||||
| ROA2 | ROA2 | ROA3 | ROA3 | ROA0c | ROA3 | ROA3 | ROA1 | ROAc | ||||||
| ROA3 | ROA3 | ROA3 | ||||||||||||
| hnRNP-C | RLY | RLY | RLY | RLY | RLYLa | RLYa | RLYLa | ROC | ||||||
| RLYL | RLYL | RLYL | RLYL | RLYLb | RLYb | RLYLb | ||||||||
| ROC | ROC | ROC | ROCa | RLYLa | ROC | |||||||||
| ROCL | ROCb | RLYLb | ||||||||||||
| ROCa | ||||||||||||||
| ROCb | ||||||||||||||
| hnRNP-D-U2 | ROAB | ROAB | ROAB | ROABa | ROABa | ROAB | ROABa | ROAB | RO40 | RO40 | RODU2 | RODa? | ||
| ROD0 | ROD | ROD0 | ROABb | ROABb | ROD0 | ROABb | ROD | RODb? | ||||||
| RODL | ROD0 | RODL | RODL | ROD0 | RODL | ROD0 | ||||||||
| RODL | ||||||||||||||
| hnRNP-E | PCB1 | PCB1 | PCB1 | PCB3 | PCB2a | PCB2 | PCB2 | PCB | PCB | PCB | PCB | |||
| PCB2 | PCB2 | PCB2 | PCB2b | PCB3 | PCB3a | |||||||||
| PCB3 | PCB3 | PCB3 | PCB3a | PCB3b | ||||||||||
| PCB4 | PCB4 | PCB4 | PCB3b | |||||||||||
| PCB4a | ||||||||||||||
| PCB4b | ||||||||||||||
| hnRNP-F-H | GRSF1 | GRSF1 | GRSF1 | GRSF1 | GRSF1 | GRSF1 | GRSF1 | ROFHa | ROFH | ROFH | ROFHa | ROFHa | ROFHa? | |
| ROF | ROF | ROF | ROH1 | ROFH | ROFHa | ROFH | ROFHb | ROFHb | ROFHb | ROFHb? | ||||
| ROH1 | ROH1 | ROH1 | ROH3 | ROH3 | ROFHb | ROH3 | ||||||||
| ROH2 | ROH2 | ROH2 | ROH3 | |||||||||||
| ROH3 | ROH3 | ROH3 | ||||||||||||
| hnRNP-G | ROG | ROG | ROG | ROG | ROG | ROG | ROG | |||||||
| ROGT | ROGT | ROGT | ||||||||||||
| hnRNP-I | PTB1 | PTB1 | PTB1 | PTB1 | PTB1a | PTB1a | PTB1 | PTBa | PTB | PTB | PTB | PTBa | PTBa? | |
| PTB2 | PTB2 | PTB2 | PTB2 | PTB1b | PTB1b | PTB2 | PTBb | PTBb | PTBb? | |||||
| ROD1 | ROD1 | ROD1 | ROD1 | PTB2 | PTB2a | ROD1 | PTBc | PTBc? | ||||||
| smPTB | smPTB | ROD1 | PTB2b | |||||||||||
| ROD1 | ||||||||||||||
| hnRNP-K | ROK | ROK | ROK | ROKa | ROKa | ROKa | ROK | ROK | ROK | ROK | ||||
| ROKb | ROKb | ROKb | ||||||||||||
| hnRNP-L | ROL | ROL | ROL | ROL | ROLa | ROL | ROL | ROL | ROL | |||||
| ROLH | ROLH | ROLH | ROLHa | ROLb | ROL | |||||||||
| ROLHb | ROLH | |||||||||||||
| hnRNP-M | Myel | Myel | Myel | Myel | Myel | Myel | Myel | ROM | ROM | ROM | ROM | ROM? | ||
| ROM | ROM | ROM | ROM | ROM | ROM | ROM | ||||||||
| hnRNP-R | ROQ | ROQ | ROQ | ROQ | ROQa | ROQ | ROQa | ROQR | ROQR | ROQR | ROQR | ROQRa | ||
| ROR | ROR | ROR | ROR | ROQb | ROR | ROQb | ROQRb | |||||||
| ROR | ROR | ROQRc | ||||||||||||
| hnRNP-U | E1BA | E1BA | E1BA | E1BA | E1BAa | E1BA | ROUa | ROU | ROU | ROU | ||||
| ROU | ROU | ROU | ROU | E1BAb | ROU | ROUb | ||||||||
| ROUHY | ROUHY | ROUHY | ROUH | ROU0 | ROUHY | |||||||||
| ROUa | ||||||||||||||
| ROUb | ||||||||||||||
| Musashi | MUS1 | MUS1 | MUS1 | MUS1 | MUS1 | MUS1 | MUS1 | MUSa | MUS | MUS | MUS | |||
| MUS2 | MUS2 | MUS2 | MUS2 | MUS2a | MUSb | |||||||||
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MUS2b
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Detailed identification of each gene is provided in Table S2. Small termination characters identify species/phylum specific duplications. None of the analyzed hnRNP genes was found for Saccharomyces cerevisiae and Plasmodium falciparum.
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↵a Proteins signed with `?' are technically orthologs (reciprocal BLAST hit) but the large evolutionary distance (and low sequence similarity) and the absence of experimental data does not allow us to classify them as functional homologs
