Functional associations between components of RefSeq transcriptional chimeras supported by ESTs
|
|
|
No. RT-PCR positives |
Physical associationa |
Functional associationb |
Related gene fusionsc |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chimera |
No. ESTs |
Same/orth. |
COG |
Same/orth. |
COG |
Fusion |
Organism |
||||
| NME1–NME2 | 4 | 7 | Yes | Yes | TXN-NDK(3) | HS, MM | |||||
| NDK-DSCAML1 | MM | ||||||||||
| ELA3A–ELA3B | 1 | — | Yes | Yes | SMO/FZD-Trypsin like | HS | |||||
| Fibrillin-trypsin like | HS | ||||||||||
| Scavenger receptor-trypsin like | HS | ||||||||||
| BHMT2–BHMT | 1 | — | Yes | Yes | BHMT-Methionine synthase | HS, MM, CE | |||||
| ACAD10–ALDH2 | 1 | 1 | No | Yes | No | Yes | ALDH-ADH | Prokaryotes | |||
| PRODH-ALDH | Prokaryotes | ||||||||||
| HAD-APH-ACAD | HS, MM, CE | ||||||||||
| ASL–RCP9 | 1 | — | No | Yes | No | Yes | NAD oxidoreductase-RPC17 | CE | |||
| GIMAP2–GIMAP1 | 1 | No | No | Yes | |||||||
| PLCXD2–PHLDB2 | 2 | 1 | No | No | Yes | ||||||
| DTX2–PMS2L5 | 2 | 1 | No | Yes | No | Yes | 5′–3′ exonuclease-helicase | Prokaryotes | |||
| SENP3–EIF4A1 | 1 | — | No | Yes | No | Yes | |||||
| HIF1A–SNAPC1 | 1 | — | No | No | No | Yes | |||||
| MIA–RAB4B | 1 | — | No | No | No | Yes | |||||
| SLC2A11–MIF | 1 | — | No | No | No | Yes | MIF-PGLYRP | MM | |||
| HSPH1–PREI3 | 2 | 1 | No | No | No | Yes | |||||
| SNTB2–VPS4A | 1 | — | No | No | No | Yes | |||||
| ATP6V0C–CGI-14 | 1 | — | No | No | No | Yes | |||||
| TMPIT–STYXL1 | 2 | 2 | No | No | No | Yes | |||||
| FPGT–TNNI3K
|
3
|
4
|
No
|
No
|
No
|
Yes
|
|
|
|||
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↵a Physical interactions between components or their orthologs (Same/orth.) or proteins within Clusters of Orthologous Sequences (COG) were retrieved from BIND databases (http://bind.ca/). These associations can be either direct, or as part of multi-subunit complexes. For interactions for which only yeast two-hybrid data are available, only those with high-confidence were considered
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↵b Functional associations between chimera components or proteins within COGs were inferred from the STRING server (http://string.embl.de/) and from the KEGG metabolic pathways database
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↵c Previously described fusions involving one of the two partners of the tandem chimeras are shown on the first column. Information for gene fusions was retrieved from STRING (http://string.embl.de/). (HS) Homo sapiens; (MM) Mus musculus; (CE) Caenorhabditis elegans
