Table 2.

Data flow of the computational search for transcription-induced chimeras

Process^a	Resulting data
1 Data download	cDNA data from GenBank version 136
2 Alignment and clustering	26,057 clusters^b of expressed sequences aligned to the genome
3 Sense/antisense separation	29,613 clusters on separate strands
4 Computational detection of gene fusion	322 pairs of fused genes
5 Filtering out alignment artifacts	281 pairs of fused genes
6 Manual filtration of artifacts	Final data set: 212 pairs of fused genes

↵a Procedures were performed as described in the Methods section
↵b A “cluster” is a group of ESTs that overlap on the genome and contains at least one RNA sequence

Transcription-mediated gene fusion in the human genome