Transcription-mediated gene fusion in the human genome

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Figure 1.
Figure 1.

A model for transcription-induced chimerism. The transcribed region spans both consecutive genes. When the pre-mRNA is spliced, it involves a 5′ splice site at the upstream gene and a 3′ splice site at the downstream gene, thus removing the intergenic region from the mature fused mRNA. The product is a hybrid mRNA containing exons from both genes.

This Article

  1. Published in Advance December 12, 2005, doi: 10.1101/gr.4137606 Genome Res. 16: 30-36

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