Independent intrachromosomal recombination events underlie the pericentric inversions of chimpanzee and gorilla chromosomes homologous to human chromosome 16

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Figure 7.
Figure 7.

Model to explain the pericentric inversion of the gorilla chromosome (GGO XVI) homologous to HSA 16. P2 indicates the position of the inversion breakpoint on PTR XVIq. The numbers indicate the nucleotide positions of BAC clones RP11-696P19 and CTD-2144E22. (A) Breakpoint-spanning HSA BACs RP11-696P19 and CTD-2144E22 are indicated by blue and red lines, respectively. The black arrows denote the 23-kb inverted repeats at the breakpoints, which are postulated to have mediated intrachromosomal recombination underlying the inversion (B). The result of this recombination is the inversion on GGO XVI as shown in (C). cen, centromere.

This Article

  1. Genome Res. 15: 1232-1242

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