FISH analyses designed to follow the evolutionary history of the region represented by HSA BAC RP11-696P19. (A) Ideogram of the chromosome I and chromosome XVI homologs in Macaca fascicularis (MFA), Pongo pygmaeus (PPY), Gorilla gorilla (GGO), Pan troglogdytes (PTR), and Homo sapiens (HSA). The positions of the regions homologous to HSA BAC RP11-696P19, as determined by FISH, are schematically indicated in green. The red crosses indicate the occurrence of the respective rearrangements (B) FISH hybridization pattern of human BACs RP11-696P19 (green) and RP11-44I10 (red) from 16q11-12 on chromosome 16 (left) and 1 (right) homologs. In metaphase spreads of MFA and PPY, signals from RP11-696P19 were found exclusively on chromosome I.
