Hypothetical model to explain the pericentric inversion of PTR XVI homologous to HSA 16. (A) Breakpoint-spanning HSA BACs RP11-696P19 and CTD-2144E22 are indicated by blue and red lines, respectively. The black arrows denote the 23-kb inverted repeat comprising repetitive elements and HSATII satellite DNA. The high degree of similarity conferred by the inverted repeats may have brought the chromosomal regions 16p11-p12 and 16q11-q12 together, thereby mediating an intrachromosomal recombination event (B). The numbers indicate the nucleotide positions according to the numbering of BAC clones RP11-696P19 and CTD-2144E22. (C) Schematic of the rearrangement on PTR XVI resulting from the recombination between the p- and q-arms. cen, centromere.
