Why do human diversity levels vary at a megabase scale?

Table 3.

Percentage of bootstraps over 3-Mb windows for which recombination remains a stronger predictor of the residuals of human diversity with errors added than chimpanzee diversity after regression on divergence



Pmin-human ≥ βchimp)
λ
Clint diversity
Central-Western diversity
1/100,000 99.24 99.19
1/50,000 93.33 99.65
1/25,000 71.28 98.45
1/10,000
0.10
29.20
  • Chimpanzee diversity estimates come from two sources: the comparison of two chromosomes of Clint and comparisons between Central and Western chimpanzees (see Methods). λ reflects the mean probability of an incorrect base call, which was estimated to be ~1/100,000 (see Methods). As can be seen, only by adding unrealistic levels of error does the relationship of human diversity and recombination become as weak as the relationship of chimpanzee diversity and recombination.

This Article

  1. Genome Res. 15: 1222-1231

Preprint Server