Figure 3.
Quantitative allele frequency estimation based on analyses of mixed templates. (Upper panel) The number of heterozygous SNPs detected in mixtures containing varying amounts of the constitutional and tumor DNAs is shown with the number of heterozygous SNPs indicated in each of the four regions. (Bottom panel, bar-graph) The total number of heterozygous SNPs increases above that seen in tumor DNA (only two) when tumor DNA is contaminated with 15% normal (blood) DNA. The number increases linearly as the percentage of contaminating normal (blood) is increased to 45%.
