Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics

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Figure 2.
Figure 2.

De novo motif identification. (A) Histogram of the 159 predictions correlated to known motifs we identified by optimizing randomly generated input alignments. (B) Sequence Logo (Schneider and Stephens 1990) of a novel motif generated by using our algorithm. (C) The sequence logo for the same motif after undergoing an additional 25 rounds of selection.

This Article

  1. Genome Res. 15: 1145-1152

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