Table 2.
Summary of lethal and fitness mutations
|
Group |
Stage |
Defect onset |
Mutation |
Phenotype |
Rw/+*× Rw/+* |
||
|---|---|---|---|---|---|---|---|
| Rw
|
nonRw
|
||||||
| Early | Pre/Peri-implantation | E3.5-E5.5 | L5Jcs4 | 78 | 0 | ||
| L5Jcs7 | 92 | 0 | |||||
| L5Jcs10 | 123 | 0 | |||||
| L5Jcs14 | 104 | 1* | |||||
| L5Jcs22 | 60 | 0 | |||||
| L5Jcs24 | 122 | 0 | |||||
| L5Jcs25 | 72 | 0 | |||||
| L5Jcs27 | 59 | 0 | |||||
| L5Jcs30 | 82 | 0 | |||||
| L5Jcs31 | 40 | 0 | |||||
| L5Jcs35 | 33 | 0 | |||||
| Post-implantation | E5.5-E7.5 | L5Jcs6 | Gastrulation | 59 | 0 | ||
| L5Jcs8 | 95 | 0 | |||||
| L5Jcs11 | Gastrulation | 64 | 0 | ||||
| L5Jcs18 | Gastrulation | 82 | 1* | ||||
| L5Jcs36 | 29 | 0 | |||||
| L5Jcs38 | Gastrulation | 63 | 0 | ||||
|
|
Undetermined
|
Pre E9.5-10.5
|
L5Jcs5
|
|
48
|
0
|
|
| Middle | Midgestation | E8.5-E12.5 | L5Jcs2 | 64 | 0 | ||
| L5Jcs3 | 97 | 0 | |||||
| L5Jcs13 | 112 | 0 | |||||
| L5Jcs15 | CF/CV/placenta | 120 | 0 | ||||
| L5Jcs17 | Growth retardation | 55 | 0 | ||||
| L5Jcs23 | NTD | 57 | 1 | ||||
| L5Jcs28 | Growth retardation | 63 | 0 | ||||
| L5Jcs32 | NTD; pericardial edema | 35 | 0 | ||||
| L5Jcs33 | CF/CV | 32 | 2 | ||||
|
|
|
|
L5Jcs37
|
CF/CV/placenta
|
20
|
0
|
|
| Late | E10.5-birth | L5Jcs20 | 38 | 0 | |||
| L5Jcs34 | 30 | 1 | |||||
| Perinatal | E18.5-1dpp | L5Jcs1 | Skeletal, bone defects | 141 | 0 | ||
|
|
Postnatal
|
1dpp-10dpp
|
L5Jcs16
|
Fitness, runty
|
69
|
0^
|
|
| UNK | L5Jcs29 | 61 | 2 | ||||
| L5Jcs26 | 33 | 0 | |||||
| L5Jcs12 | 53 | 0 | |||||
| L5Jcs19 | 73
|
0
|
|||||
|
|
|
|
|
Total
|
2215
|
8
|
|
-
↵(*) Sickly; (^) no runts at wean age; (CF) craniofacial; (CV) cardiovascular; (NTD) neural tube defects.
