Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle

Table 3.

Effect of ABCG2(2) on the breeding values of the daughters of the heterozygous sires and QTL effects derived from the animal model analyses





Quantitative traits
Analysis
Genotypea
Number of cows
Kg milk
Kg fat
Kg protein
% Fat
% Protein
Class effectsb -/- 78 0 0 0 0 0
+/- 328 -185 0.4 1.2 0.059 0.065
+/+ 264 -432**** 4.2** 3.3** 0.169**** 0.145****
% Dominancec 14.3 80.9 27.3 30.2* 17.2*
Regressiond 670 -226**** 2.6** 1.8** 0.093**** 0.076****
Animal modeld


-597
2.2
1.3
0.225
0.193
  • Significance: *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

  • a 581S was denoted the “-” QTL allele; Y581 was denoted the “+” QTL allele

  • b Significance of the class effect is indicated in the +/+ row. Effects are computed relative to the -/- homozygote

  • c Relative to the -/- homozygote

  • d Allele substitution effects assuming additivity

This Article

  1. Genome Res. 15: 936-944

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