Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle

Table 2.

Effects of the polymorphisms on the bulls' breeding values for the quantitative traits with each marker analyzed separately





Quantitative traits
Marker
Number of bulls
Frequency of the more common allele
Milk
Fat
Protein
% Fat
% Protein
BM143a 346 55.1 -34 0.7 -3.5** 0.019 -0.022*
MLR1 298 50.5 -67 -2.8 0.7 -0.005 0.025*
MED28 316 57.2 80 6.0*** 4.4*** 0.031 0.018*
LAP3 341 57.3 13 6.1** 4.7*** 0.053** 0.039****
IBSP 336 61.3 -35 1.1 0.6 0.021 0.015
SPP1(1) 366 57.0 -123** -0.1 0.8 0.039* 0.043****
SPP1(2) 309 72.9 -171** -0.7 1.4 0.048* 0.061****
PKD2 326 67.1 -141** 0.6 0.9 0.046* 0.048****
ABCG2(2)b 335 80.5 -341**** 5.3* 4.1** 0.159**** 0.135****
ABCG2(1) 282 55.4 -67 0.8 2.4 0.029 0.042****
PPMIK 369 73.6 -58 -1.7 1.8 0.001 0.033**
HERC6 328 67.9 -14 4.9** 5.6**** 0.049** 0.056****
FAM13A1(1) 381 81.8 -64 0.3 1.1 0.023 0.028*
FAM13A1(2)
370
41.1
-107*
2.0
1.2
0.053**
0.042****
  • Significance: *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

    For all the other markers, the effects were computed relative to the allele in LD association with the + allele for ABCG2(2).

  • a This microsatellite was analyzed as a diallelic marker as described in the Supplemental data

  • b For ABCG2(2) effects were computed relative to the Y581 allele. This allele, denoted the + allele, was associated with increased protein concentration

This Article

  1. Genome Res. 15: 936-944

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