Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle

Table 1.

Polymorphism detection in the course of positional cloning the QTL on BTA6



Number of exons

Sequencing size (bp)

Polymorphism
Gene
Total
Sequenced
Exons
Introns
Promoter
Typea
Location
MLR1 7 2 482 228 Insertion TGAT Exon 7 (AJ871966)
MED28 5 2 133 1268 C to T Exon 4 (AJ871964)
LAP3 13 2 147 450 C to T Exon 12 (AJ871963)
IBSP 7 1 560 A to G Exon 7 (NM_174084b)
SPP1(1) 7 7 1362 5633 1205 A to G Intron 5 (AJ871176)
SPP1(2) T to G Exon 7 (AJ871176)
PKD2 15 15 3023 2485 2931 Insertion A Promoter (AJ871176)
ABCG2(1) 16 15c 2029 3416 A to T Intron 3 (AJ871176)
ABCG2(2) A to Cd Exon 14 (AJ871176)
PPMIK 7 1 490 GC to AT Exon 2 (AJ871967, AJ871968)
HERC6 23 330 Insertion C Intron 5 (AJ877268)
FAM1 3A1(1) 18 18 2580 2190 A to G Intron 9 (Cohen et al. 2004a)
FAM1 3A1(2) C to A Exon 12 (Cohen et al. 2004a)
Total


10,806
16,713
4136


  • a The more frequent allele is listed first

  • b At position 802

  • c Coding region of this gene starts in exon 2

  • d Y581S

This Article

  1. Genome Res. 15: 936-944

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