Table 2.

The locations and scores of ultraconserved elements in the CFTR locus

Start^a	Length	RS score	Type	Gene	Chick hit^c
747185	1442	2037	CDS/3′UTR	CAPZA2	792, 72%
1019532^b	978	1606	Intron/CDS	ST7	972, 73%
988235	957	1450	Intronic	ST7	NA
1620561	895	1446	CDS	CORTBP2	904, 79%
528543	1284	1286	CDS	CMET	1289, 69%
1047144	553	1158	Intronic	ST7	NA
966907	992	1120	Intronic	ST7	492, 60%
183738	693	1114	Intergenic	TES–CAV2	428, 75%
1145460	935	1067	Intronic	WNT2	NA
1150910	593	813	Intronic	WNT2	250, 70%
1421330	888	807	Intronic/CDS	CFTR	748, 68%
388452^b	392	774	CDS	CAV1	368, 80%
611415	821	754	Intronic/CDS	CMET	358, 65%
1002497	554	719	Intronic	ST7	428, 71%
1540687	637	717	CDS/3′UTR	CORT2	628, 68%
534395	723	702	Intronic	CMET	559, 67%
963235	955	692	Intronic/CDS	ST7	668, 57%
604385	476	649	Intronic/CDS	CMET	314, 71%
1613714^b	362	644	Intronic/CDS	CORT2	349, 79%
527928	608	575	Intronic	CMET	NA

↵a First position of the human sequence is set as position 1
↵b Regions containing elements meeting the ultra-constrained criterion using original merging parameters (see Methods)
↵c Values reported are the lengths of the HSPs and their corresponding percent identities (see Methods)

Distribution and intensity of constraint in mammalian genomic sequence