Philippe P. Luedi; Alexander J. Hartemink; Randy L. Jirtle

Table 1.

Homologs of imprinted gene candidates showing linkage to human conditions

Condition	Chromosome	Locus	Coordinate	Expression^a,^b	Linkage	Reference
Alzheimer	10p11	D10S1208	35.3	m	linkage to late-onset Alzheimer disease (AD)^b	Bassett et al. (2002)
		Epc1	32.6	M
		C1 orf9	35.7	M
Atopy	13q14	D13S161	46.7	p	linkage to atopy^b	Bhattacharyya et al. (2000)
		LCP1	45.6	P
Autism	9p22	D9S157	17.6	p	linkage to autism^b	Lamb et al. (2005)
		C9orf39	17.1	P
Bipolar	13q13	D13S1493	32.9	m	linkage to bipolar disorder^b	McInnis et al. (2003)
		Q5TBK1	31.9	M
	18q22	D18S878	61.6	p	linkage to bipolar disorder^b	McInnis et al. (2003)
		SERPINB2	59.7	M
Diabetes	11q13-14	D11S2371-D11S2002	73.2-79.6	p	linkage to birth weight (indirectly to diabetes)^b	Lindsay et al. (2002)
		NEU3	74.4	M	mice overexpressing Neu3 develop diabetic phenotype	Sasaki et al. (2003)
		OR2AT4	74.5	M
		CAPN5	76.5	M
Homosexuality	10q26	D10S217	129.4	m	linkage to male sexual orientation^b	Mustanski et al. (2005)
		C10orf90	128.1	P
		STK32C	133.9	M
		NKX6-2	134.4	M
Obesity	10p12	D10S197	26.5	m	linkage to obesity^b	Dong et al. (2005)
		GAD2	26.5	M	candidate gene for obesity	Boutin et al. (2003)
Paternal UPD	14q12	D14S608	27.9		paternal UPD results in fetal malformations^b	Kurosawa et al. (2002)
		NOVA1	26.0	M
		FOXG13	28.3	P
Schizophrenia	2p12	D2S139	76.7	p	linkage to relative hand skill^b, Tourette syndrome and schizophrenia	Francks et al. (2003); Simonic et al. (2001); DeLisi et al. (2002)
		LOXL3	74.7	M
		DOK1	74.7	P
		HK2	75.0	M
		TACR1	75.2	P
	22q12	D22S283	35.1	m	linkage to schizophrenia^b	DeLisi et al. (2002)
		Q96PY3	36.1	P
		C22orf23	36.7	M
Thrombosis	5q13	D5S2003	74.6	m	linkage to high FVIII levels^b	Berger et al. (2005)
		Q9P109	74.4	M
	9q22	D9S910	98.6	p	linkage to high FVIII levels^b	Berger et al. (2005)
		SAMD6	98.6	P
		ALG2	99.1	M
		NR4A3	99.7	P
		TXNDC4	99.8	P
	11q21	D11S4176	93.7	m	linkage to high FVIII levels^b	Berger et al. (2005)
		JMJD2D	94.4	M

Assignment of cytogenetic band and coordinates (in megabases) is based on Ensembl version 29.35b.
↵a Genes predicted to be expressed from the maternal allele are denoted by M, paternally expressed genes by P.
↵b Parent-of-origin effect was observed (m and p denote maternal and paternal effects, respectively).

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